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Monkeypox

Monkeypox virus (MPXV) is a zoonotic double-stranded DNA enveloped virus that belongs to the orthopoxvirus genus of the Poxviridae family, which also includes variola (VARV), cowpox (CPX), and vaccinia (VACV) viruses. The monkeypox virus is endemic to Africa with two distinct genetic groups (clades): the west African clade and the central African (Congo Basin) clade.

For the second time in two years, the WHO has declared a global health emergency for mpox (monkeypox) virus, due to a newly emerging, highly contagious strain spreading across Africa. PCR is the only available FDA-approved test known to detect mpox virus, but it has limitations including complex sample collection and the requirement for sophisticated equipment and trained personnel. A rapid test, needing only a small sample of lesion swab and delivering results in 15 minutes, could dramatically slow the rate of transmission of the virus. Several immunodominant proteins for mpox have been identified and antibodies to the MPXV A29L protein have shown promise in lateral flow assays for the specific detection of mpox without cross-reactivity to other Orthopoxviruses. (doi.org/10.3389/fcimb.2024.1414224).

Meridian has paired MAbs to Mpox A29L that are ideal for ELISA or lateral flow applications, alongside recombinant antigens to mpox proteins P4a, A5L, A11L, H3L, and A29L for IgM testing.

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Monkeypox Products (7)

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	Name	Type	Format	Host/Source	Isotype	Tested Apps	Unit	Catalog	Buffer	Immunogen	Recombinant	Description	Notes	Safety Data Sheet	COA/Test Release	Product Information Sheet	New Product	Recommended Product	Order a Sample
	MONKEYPOX A5L & A11L FUSION Ag	Antigen	Purified	E. coli	N/A	EIA,WB	BO	R01805	50 mM Tris-HCl, 100 mM Sodium Chloride, pH 8.0.		No	Monkeypox A5L and A11L Fusion Ag Monkeypox A5L and A11L Recombinant Fusion Antigen Contains a proprietary tag at the N-Terminal. Apparent Molecular Weight ~ 53 kDa on a 12% reducing SDS-PAGE.		Safety Data Sheet —	COA/Test Release	—	0	0
	MONKEYPOX H3L RECOMBINANT Ag	Antigen	Purified	E. coli	N/A	EIA,WB	BO	R01806	50 mM Tris-HCl, 100 mM Sodium Chloride, pH 8.0.		Yes	Monkeypox H3L Recombinant Ag. Monkeypox Virus H3L Recombinant Antigen Contains a proprietary tag at the N-Terminal. Apparent Molecular Weight ~ 53 kDa on a 12% reducing SDS-PAGE.		Safety Data Sheet —	COA/Test Release	—	0	0
	MONKEYPOX P4a RECOMBINANT Ag	Antigen	Purified	E. coli	N/A	EIA,WB	BO	R01807	50 mM Tris-HCl, 100 mM Sodium Chloride, pH 8.0.		Yes	Monkeypox P4a Recombinant Ag Monkeypox Virus P4a Recombinant Antigen Contains a proprietary tag at the N-Terminal. Apparent Molecular Weight: ~ 80 kDa on a 12% reducing SDS-PAGE.		Safety Data Sheet —	COA/Test Release	—	0	0
	mAb to Monkeypox A29L	Monoclonal	Purified, Liquid	Mouse	IgM,k	EIA,LF	MG	BN1206	Phosphate Buffered Saline, pH 7.3	Recombinant MPXV A29L Protein	No	Monoclonal Antibody to Monkeypox Virus A29L Protein		Safety Data Sheet —	COA/Test Release	—	0	0
	mAb to Monkeypox A29L	Monoclonal	Purified, Liquid	Mouse	IgG1,k	EIA,LF	MG	BN1207	Phosphate Buffered Saline, pH 7.3	Recombinant MPXV A29L Protein	No	Monoclonal Antibody to Monkeypox Virus A29L Protein		Safety Data Sheet —	COA/Test Release	—	0	0
	Monkeypox A29L Rec. Ag	Antigen	Purified	HEK Cells	N/A	EIA,LF	MG	BN1179	Phosphate Buffered Saline, pH 7.3		Yes	Monkeypox Virus A29L Recombinant Antigen, C-terminal His-tag Molecular Weight: 13 kDa		Safety Data Sheet —	COA/Test Release	—	0	0
	Monkeypox A29L Rec. Ag	Antigen	Purified	HEK Cells	N/A	EIA,LF	MG	BN1180	Phosphate Buffered Saline, pH 7.3		Yes	Monkeypox Virus A29L Recombinant Antigen, C-terminal His-tag Molecular Weight: 13 kDa		Safety Data Sheet —	COA/Test Release	—	0	0

Pairs table for "Monkeypox"

Capture Antibody	Detection Antibody
BN1206	BN1207
BN1206	BN1207

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Monkeypox Diagnosis and Prevention

Monkeypox is primarily diagnosed by molecular testing using PCR. However, very recent research suggests that monkeypox infections can be asymptomatic, which indicates the potential need for wider testing and isolation policies among people exposed to the virus (https://doi.org/10.1101/2022.07.04.22277226). If screening expands to individuals exposed to active monkeypox cases, then testing may need to include molecular testing on blood specimens and serology-based immunoassays that can detect acute subclinical and asymptomatic infections. In previous monkeypox outbreaks, such as the one in 2003 in the United States, serologic assays provided significant diagnostic support. Monkeypox IgM capture assays were able to distinguish between vaccinated and unvaccinated individuals with a sensitivity and specificity of 95% (https://doi.org/10.1128/CDLI.12.7.867-872.2005).

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