Choose a country to view content specific to your location
Choose a country to view content specific to your location
Thyroglobulin (Tg) is a dimeric protein produced by the follicular cells of the thyroid and accounts for approximately half of the protein content of the thyroid gland. It is the precursor for the thyroid hormones T3 and T4 and each Tg molecule forms approximately 10 thyroid hormone molecules.
Contact us to learn more about Meridian’s molecular or immunoassay reagent portfolio. We want to hear from you!
Thyroglobulin is normally produced at low levels by the thyroid gland. Certain autoimmune disease such as Graves’ disease, Hashimoto thyroiditis, and other diseases including subacute thyroiditis and thyroid cancer cause high levels of thyroid hormone. Anti-thyroglobulin antibody tests are used to measure antibodies produced in response to thyroid autoimmune disease and the thyroglobulin assay is mostly used as a tumor marker test to monitor patients with well differentiated thyroid cancers (particularly papillary or follicular thyroid cancer) and to determine metastasis. Tg assays can also be used to detect deficient thyroglobulin synthesis in infants with goitrous hypothyroidism, which is a preventable cause of mental retardation.
Tg serum levels are measured by two-site sandwich immunoassays. However, quantitative Tg serum assays are prone to interference from endogenous circulating autoantibodies (anti-Tg) and can cause inappropriately low Tg results in about 20% to 30% of patients. In suspected cases of interference, a confirmatory test detecting the presence of anti-Tg should be carried out.
Anti-thyroglobulin antibody tests are generally used in combination with other tests such as anti-thyroid peroxidase (anti-TPO) to examine thyroid function for autoimmune thyroid disorders and distinguish it from other forms of thyroiditis.
Have questions about a product? Want to learn more about Meridian’s molecular or immunoassay reagent portfolio? We want to hear from you!
By submitting your information in this form, you agree that your personal information may be stored and processed in any country where we have facilities or service providers, and by using our “Contact Us” page you agree to the transfer of information to countries outside of your country of residence, including to the United States, which may provide for different data protection rules than in your country. The information you submit will be governed by our Privacy Statement.
| Type |
|---|
| Format |
| Host/Source |
| Isotype |
| Tested Apps |
| Unit |
| Catalog |
| Buffer |
| Immunogen |
| COFA Description |
| COFA Notes |
| Recombination |
| SDS |
| COA |
| Product Information Sheet |
| Request Sample |
